Gertsch Group - Latest Blog Comments en-us Recently been invited to give a talk at a congress? - jimmy <p> Great work! I want to say that you have created very interesting information. Keep this great work up. <a href=""></a> is the best services provider.</p> Sat, 24 Jun 2017 09:06:18 +0200 /blog/entry/2385963/recently-been-invited-to-give-a-talk-at-a-congress#comment4358835 On concentration - Kumar <p>Do not agree with Philippe - you see things in vitro that are non-physiological because you increase your concentration. The misuse of doses and concentrations are a big problem in biological research.</p> Thu, 01 Jun 2017 16:09:25 +0200 /blog/entry/3813596/on-concentration#comment4353157 How do Paederus beetles cope with pederin? - jayantibhai patel <p>Blister Beetle dermatitis and Paedrus dermatitis are two different diseases .Former is due to canthardin and later to Paedrin.Mode of action of both chemicals are different. Rove beetles have pederin in hemolymph when it crushed on skin then Paedrin comes into the contact of skin and symptoms appears after 24 hours and linear in shape.Blister beetle can have canthardin not only in hemolymph in the body but also at joints of legs.They are larger beetles so it produces larg lesion and symptoms appear within 24 hours.</p> Mon, 17 Apr 2017 14:38:52 +0200 /blog/entry/627901/how-do-paederus-beetles-cope-with-pederin#comment4341390 How random is your life - David Brown <p>&quot;We simply like to believe what we want to believe - so even much of science is probably a reflection of what our wishful thinking is trying to suggest because interpretation of data is rarely done at the basis of probability.&quot;</p> <p>Exactly. That's a big problem, is it not? Need more scientists who amalgamate.</p> Sun, 26 Mar 2017 18:44:53 +0200 /blog/entry/250051/how-random-is-your-life#comment4335827 Lipids in Fetal Bovine Serum (FBS) - Exploring the Black Box - Jurg Gertsch <p>Hi Janet, to my opinion there is no such thing as a total fatty acid content of FBS. There are numerous lipids in FBS and they vary with batch and if you need to know them you have to measure them. </p> Mon, 23 Jan 2017 15:35:31 +0100 /blog/entry/2197993/lipids-in-fetal-bovine-serum-fbs-exploring-the-black-box#comment4319881 Beauty in mathematics, beauty in nature <p>Good aritlce</p> Mon, 28 Nov 2016 13:18:02 +0100 /blog/entry/414741/beauty-in-mathematics-beauty-in-nature#comment4306803 Recently been invited to give a talk at a congress? - Jurg Gertsch <p>Looks as if Biochem 2016 is going to happen in Texas - maybe it started as scam and turned into something real ... strange that this is about &quot;biochem&quot; as it is more a mix of several topics, kind of weird.</p> Fri, 25 Nov 2016 11:28:13 +0100 /blog/entry/2385963/recently-been-invited-to-give-a-talk-at-a-congress#comment4306265 Recently been invited to give a talk at a congress? <p>Is biochem congress a scam too <br />In texas next month</p> Wed, 23 Nov 2016 10:41:27 +0100 /blog/entry/2385963/recently-been-invited-to-give-a-talk-at-a-congress#comment4305872 On concentration - Philippe <p>Hi, I do not really fully agree with your comment. I think that higher concentrations used in research can still uncover relevant targets and sometimes you just need to increase your concentration to make things visible. Also, the in vitro situation is artificial too and you cannot simulate the real physiological situation in any case. </p> Mon, 12 Sep 2016 17:04:12 +0200 /blog/entry/3813596/on-concentration#comment4295079 Toxic effect with BIA-10-2474 first seen at 50 mg dose <p>nice </p> Tue, 02 Aug 2016 21:06:05 +0200 /blog/entry/3949694/toxic-effect-with-bia102474-first-seen-at-50-mg-dose#comment4287700 Don't publish with preditory publishers - Xavier 87 <p>Scientific spam is getting crazy - really hard for naive young scientists to know what is real. Thanks for the link!</p> Sun, 12 Jun 2016 10:20:04 +0200 /blog/entry/3732610/dont-publish-with-preditory-publishers#comment4280062 Toxic effect with BIA-10-2474 first seen at 50 mg dose - Norma Jonathan <p>Maybe the toxicity is a combination effect, involving FAAH plus one other target. </p> Thu, 09 Jun 2016 17:28:36 +0200 /blog/entry/3949694/toxic-effect-with-bia102474-first-seen-at-50-mg-dose#comment4279679 How do Paederus beetles cope with pederin? - Jane <p>I live in Kenya, It is currently the rainy season and there seems to be an outbreak of this Nairobi flies. specifically in my house. I have tried to locate the entry points consequently i have sealed all the vents and possible entry points. On the net there is very little information about how these insects behave, where they live and how to control them or prevent them from entering the house. Anyone with this information on this thread any useful tips on prevention or destruction (even bio methods) will be highly appreciated</p> Thu, 21 Apr 2016 00:29:23 +0200 /blog/entry/627901/how-do-paederus-beetles-cope-with-pederin#comment4269525 On concentration - Tim <p>I see this over and over again: paper on some natural product that displays interesting inhibition of something, like NF k B for example, and then looking at the details, we see the activity is in the dozens of uM. In other words, too weak to be really useful, not something that can be dosed. With compounds active in the tens of uM, often correlates to dosing with grams of product. Single point of action can be lost with high dosages.</p> <p>That being said, there are some non-toxic natural products in the borderline region of low single digit uM, that can be dosed, corresponding to a gram or less dosages. So there is a bit of a trade off between activity and toxicity, that gives a gray area in the low uM region.</p> <p>Generally, nM activity is required for sensible dosing, to allow for losses of compound in vivo, serum protein binding, first and second pass metabolism, uneven distribution in organs/tissues and other such ADME issues.</p> <p>Unfortunately, a global standard seems to be not really possible because of the wide ranging, variable ADMEs and variable off target issues. </p> Fri, 01 Apr 2016 21:37:11 +0200 /blog/entry/3813596/on-concentration#comment4266425 The cultural history of the pipette - nirmak <p>completely robotized and electronic, multiwell and high exactness. The popular French scientific expert and microbiologist Louis Pasteur was a functional man and made his own pipettes from glass - utilizing distinctive assortments of suckers and inflatables - elastic globules called teats. Such globules are still utilized by scientific experts to titrate precise volumes from burettes, the starting point of which retreat to the eighteenth century. We all know the viable cylinder driven air-uprooting Gilson pipettes, undestroyable and relatiely exact. These micropipettes were developed at the University of Wisconsin-Madison in 1972 by individuals such as Warren Gilson and Henry Lardy. Henceforth, the greatest maker is the organization called Gilson Inc., accordingly these pipettes are casually refered to as Gilsons. A few years prior Gilson presented what they called a consistently advanced pipette and this was most likely the most noticeably bad creation they ever constructed. These pipettes all broke inside of 1-2 years. What you truly need is a powerful and simple to handle and to adjust pipette, which will transform into your dear companion throughout the years. You need to drop it and crush it on the seat, and being your companion it won't break. Alright, there are some magnificent electronic pipettes around.get mobdro app at <a href=""></a> . I imagine that the electronic Eppendorf multiwell pipettes are savvy and decent to handle yet for ordinary utilize, the Gilsons are faction and make you feel at home.</p> Tue, 15 Mar 2016 10:00:31 +0100 /blog/entry/292821/the-cultural-history-of-the-pipette#comment4264164 Lipids in Fetal Bovine Serum (FBS) - Exploring the Black Box - Janet <p>Is there anywhere I can find a total fatty acid profile of FBS? </p> Thu, 18 Feb 2016 23:45:55 +0100 /blog/entry/2197993/lipids-in-fetal-bovine-serum-fbs-exploring-the-black-box#comment4261508 Clinical Study Protocol N° BIA-102474-101 - Xu Xing <p>No stopping rules for serious adverse events is a very unusual study protocol - Laboratoire Biotrial in Rennes will have to openly discuss their errors.</p> Mon, 15 Feb 2016 19:07:02 +0100 /blog/entry/3948306/clinical-study-protocol-n-bia102474101#comment4261343 Clinical Study Protocol N° BIA-102474-101 - Phil Sanders <p>Thanks for communicating the protocol on your website</p> Wed, 27 Jan 2016 00:58:38 +0100 /blog/entry/3948306/clinical-study-protocol-n-bia102474101#comment4259502 Disaster during Phase I clinical trial with FAAH inhibitor BIA-10-2474 from the Portuguese Pharma company Bial - Crombie James <p>Deep hemorrhagic brain lesions cannot be caused via modulation of the endocannabinoid system. This compound is a killer and possibly induces irreversible blockage of multiple enzymes - I did not find any data on the selectivity of this substance!</p> Wed, 20 Jan 2016 15:47:09 +0100 /blog/entry/3944215/disaster-during-phase-i-clinical-trial-with-faah-inhibitor-bia102474-from-the-portuguese-pharma-company-bial#comment4258813 Disaster during Phase I clinical trial with FAAH inhibitor BIA-10-2474 from the Portuguese Pharma company Bial - Alessia <p>Does anyone know why the people died, for what reasons? Was it brain damage or general organ failure?</p> Tue, 19 Jan 2016 10:35:21 +0100 /blog/entry/3944215/disaster-during-phase-i-clinical-trial-with-faah-inhibitor-bia102474-from-the-portuguese-pharma-company-bial#comment4258721